I found this activity for making DNA Sequence Bracelets, but instead of making bracelets, my kids and I matched bases on our travel-size Mastermind game. One person put in the pegs for the chosen sequence, and the other person put in the matching base. This activity could also be used as a station or in groups of 2-3 students.

While this activity isn’t something wonderful to keep like a well-made bracelet, nor is it as detailed as a model showing the phosphate groups, deoxyribose, and the double-helix shape, but it’s a useful introduction to the DNA base pairing rules. Plus, it required little preparations to get the correct color pegs ready, and it cost nothing since we already had the game.